Slides

PDF renditions of the (powerpoint) presentations given at EBF's 2011 focus meeting and released for public viewing by the authors can be read and downloaded from this page.

Opening

Philip Timmerman (Janssen R&D for EBF) - Welcome and Introduction

New Technology Developments for Analysis of Large Molecules

Lieve Dillen (Janssen R&D) - Comparison of different MS platforms for peptide quantification
Debadeep Bhattacharya (Waters Corporation) - Implementation of a common high pH LC/MS/MS platform for small molecules and large molecules
Kai Scheffler (Thermo Fisher Scientific) - Introducing a novel bench top Orbitrap for highly selective peptide/protein quantitation
Lester Taylor (Agilent Technologies) - High Sensitivity Protein Quantitation Using a Triple Quadrupole with a Dual Ion Funnel

Cutting Edge Analytical Approaches - Peptides

Lee Goodwin (Covance) - Strategies for the analysis of therapeutic peptides in biofluids
Rachel Green (Quotient Bioresearch) - Comparison of clinical analyser and LC-MS/MS based approaches for quantification of serum IGF-I levels - Not Realeased for Publication
Veniamin Lapko (Celerion) - Quantitative LC-MS/MS analysis of polypeptides: glucagon
Hermann Mascher (pharm-analyt Lab. GmbH) - Quantification of selected peptides in biological fluids e.g. plasma
Gerard Hopfgartner (University of Geneva) - The importance of sample preparation for the analysis of proteins and peptides by liquid chromatography with mass spectrometric detection
Magnus Knutsson (Ferring Pharmaceuticals A/S) - LC-MS/MS bioanalysis of therapeutic peptides in plasma at low pg/mL levels
Erin Chambers (Waters Corporation) - A selective SPE/LC-MS/MS assay for simultaneous quantitation of multiple amyloid beta peptides in cerebrospinal fluid

Validation Requirements for Large Molecule Analysis with MS Techniques

Cutting Edge Analytical Approaches - Proteins

Analytical Strategies on Combining LBA and LC-MS(/MS) for Large Molecules

Proteins in the MIST

Michael Przybylski (University of Konstanz) - Ion mobility mass spectrometry: New molecular tool for the analysis of reactive intermediates in the oligomerization- aggregation of “misfolding”-aggregating proteins
Richard Kay (Quotient Bioresearch) - Strategies for quantifying plasma protease susceptible peptides by LC-MS/MS - Not Released for Publication
William van Dongen (PROXY laboratories) - Bioanalytical LC-MS of therapeutic oligonucleotides
Filip Cuyckens (Janssen R&D) - Extracting metabolite ions of peptide drugs out of an in vivo matrix background

Closing

Philip Timmerman (Janssen R&D for EBF) - Closing Remarks and Adjourn